大奖888生化目录肽版块全新呈现,致力于打造全球最全面的多肽供应平台!我们专业的学术团队将时刻追踪最新最热的研究动向,帮助您发现实际需求,并以最高质量标准提供您所需要的产品。我们将我们将不定期更新产品列表,为您最大限度地节约科研时间,敬请广大客户朋友关注!
SIGN-011
Pannexin-1 (Panx1), Mimetic Blocking Peptide
Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr
Size:1
P1(RMB):662
MW:1242.4
One letter sequence:WRQAAFVDSY
Molecular Formula:
Description:This is a Pannexin-1 (Panx1) mimetic blocking peptide. Pannexin-1 is a recently identified membrane protein that can form gap junction-like connections allowing intercellular passage of dyes when overexpressed in two adjacent oocytes or mammalian epithelial cell lines. Blockade of pannexin-1 in macrophage endogenously expressing the ATP-gated P2X7 receptor (P2X7R) blocks the initial dye uptake, but not the ionic current, and also blocks processing and release of interleukin-1? (IL-1?) in response to P2X7R activation.\n
Literature Reference:Pelegrin, P. et al. EMBO. J. 25, 5071 (2006); Pelegrin, P. et al.t J. Biol. Chem. 282, 2386 (2007).
Cas: